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KMID : 0384119870070020351
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Korean Journal of Clinical Pathology
1987 Volume.7 No. 2 p.351 ~ p.355
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A Case of Hemolytic Disease of Newborn Caused by anti-E
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Abstract
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The hemolytic disease of newborn(HDN) is characterized by hemolytic anemia and severe jaundice due to IgG antibody transmitted from the mother to the fetus across the placenta.
Anti-Rh(D) has been the most common antibody responsible for HDN, but recent￢ly incidence of HDN due to Rh(D) has become decreased due to prophylaxis of anti￢D immunoglobulin and incidence of HDN due to minor factor seems to be increased.
The 1 day did. male baby was admitted because of whole body cyanosis and prema￢turity. He was developed severe jaundice at the 2 days.
He was fifth baby and his blood type was AB, CcDEe. The his mother´s blood type was B, CcDe. The serologic examination revealed positive direct antiglobulin test and indirect antiglobulin test on the patient´s red cell and serum. The mother´s ser￢um revealed positive indirect antiglobulin test and the antibody in the maternal ser￢um was identified as anti-E via antibody screening and identification test.
After two times of exchange transfusion, the jaundice has subsided. So we report a case of HDN due to anti-E with the review of literatures.
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KEYWORD
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